Units: 2.
Quarter: Fall 2008
Location: MTF168
Time: Tuesdays, 1:00 to 2:30 PM
Course Directors: Jess Mandel, M.D.; Kenneth Kaushansky, M.D.; Jason Yuan, M.D., Ph.D.
Required readings: 2-3 key journal articles will be distributed prior to each seminar.
This course is the second in a series of two Med275 courses having the same style and focus that alternate annually in the autumn quarter. It examines 10 diseases that are different from those in Med275-A.
Both courses in the series may be taken by interested students.
Course Objectives: To educate graduate and medical trainess on the pathogenic and therapeutic mechanisms of major human diseases, highlighting the state of current research, the diagnostics and therapeutics currently employed, and the unmet diagnostic and therapeutic needs. Each lecture is preceeded by an interview of a patient with the disease being discussed. The patient describes the disease onset, symptoms, progression, therapeutics taken, therapeutic side effects, and the impact of the disease on his/her life. Students ask the patient questions for 10 minutes or so. Next, a physican-scientist lectures for an hour on the current state of known molecular mechanisms, open research questions, and diagnotic/therapeutic needs.
This course is required forMed-into-Grad students as part of their core training prior to entering the clinical training in Winter quarter. Graduate students from programs based in the School of Medicine, as well as in the undergraduate campus, are welcome to attend, as are medical students interested in translational research. The course does not focus on the “gaps”, the many diseases that lack both a defined molecular mechanism and an effective therapeutic. Med-into-Grad discover these “gaps” during Winter quarter clinical training, and use the knowledge from this class to hypothesize the most effective avenues to elucidate molecular mechanisms. During their Winter quarter clinical training, Med-into-Grad students will also use knowledge from this course, as well as from their molecular research backgrounds to envision more effective diagnostics and improved molecular or mechanical therapeutics
AT THE CROSSROADS: Science Meets the Medical Patient |
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| Course Directors: Jess Mandel, M.D.; Kenneth Kaushansky, M.D.; Jason Yuan, M.D., Ph.D. | ||||
| Course Objectives: To provide a comprehensive course on patient- and disease-oriented pathogenic and therapeutic mechanisms for graduate students who are enrolled in the HHMI Med-Into-Grad program (and other programs), and for medical students who are interested in translational research. | ||||
| Required Readings: 2-3 key journal articles will be distributed prior to each seminar. | ||||
| Date | Location | Topic | Speaker | |
| Sept 9th | MTF168 | I. |
Introduction | |
| Week 1 | Part 1 : Human Diseases: An Overview (30 min.) | Ken Kaushansky, M.D. | ||
| Part 2 : Clinical Diagnostic and therapeutic approaches (30 min.) | Jess Mandel, M.D. | |||
| Sept. 16th | MTF168 | II. |
Gastrointestinal Disease | |
| Week 2 | Diarrhea: ion transporters and signaling pathways in the pathogenesis | Kim Barrett, Ph.D | ||
| Sept. 23rd | MTF168 | III. |
Respiratory Disease | |
| Week 3 | Idiopathic and chronic thromboembolic pulmonary hypertension: Receptor signaling and transcription factors in pathogenesis |
Jason Yuan, M.D., Ph.D. Jess Mandel, M.D. |
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| Sept. 30th | MTF168 | IV. |
Cardiovascular Disease | |
| Week 4 | Coronary artery and atherosclerosis:Role of nuclear receptros | Christopher Glass, M.D./Ph.D. | ||
| Oct. 7th | MTF168 | V. |
Neurological Disease | |
| Week 5 | Alzheimer's disease | Douglas Galasko, M.D. | ||
| Oct. 14th | MTF168 | VI. |
Endocrine Disease | |
| Week 6 | Thyriod hormones and the heart | Wolfgang Dillmann, M.D. | ||
| Oct. 21st | MTF168 | VII. |
Infectious Disease | |
| Week 7 | Malaria | Joe Vinetz, M.D. | ||
| Oct. 28th | MTF168 | VIII. |
Hematological Diseases | |
| Week 8 | Myeloprofiliative diseases | Ken Kaushansky, M.D. | ||
| Nov. 4th | MTF168 | IX. |
Cancer | |
| Week 9 | Lung cancer glycobiology | Mark Fuster, M.D. | ||