Training for Careers in
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| PhD Program |
| Program Overview |
| All Faculty |
| Faculty Research Groups - Click Banner Insignias |
| Admissions |
| Info for MSTP applicants |
| Info for Current Students |
| Class Offerings |
| Curriculum |
| Financial Support |
| Annual Research Retreat |
| Research Seminars Calendar |
| Med-Into-Grad Program |
| Local Scientific Resources |
| Burnham Institute |
| The UCSD Cancer Center |
| Ludwig Institute, UCSD |
| Scripps Research Institute |
| Salk Institute |
Structural Biology and Signal Transduction Faculty Cells in the body have to communicate with each other in order to function in harmony and avoid disease and death. The goal of the Structural Biology and Signal Transduction Program is to understand the mechanisms that cells use for sending and receiving signals using networks of interconnected molecules. This knowledge can be used to repair malfunctioning signaling processes that cause disease. (Research Overview, Additional Activities)
Faculty
Ju Chen UCSD SOM PDZ & LIM proteins in cardiomyocyte function. Cardiac and skeletal muscle disease. David Cheresh UCSD SOM Molecular Basis of Angiogenesis, Vascular-Targeted Gene Delivery, Myocardial Infarction and Stroke Don Cleveland UCSD Ludwig Institute Molecular genetics of axonal growth and motor neuron disease. Molecular genetics of mammalian chromosome movement and spindle assembly Sara Courtneidge Burnham Src family kinases in normal cell biology and cancer Marcia Dawson Burnham Drug discovery, molecular targets. Synthesis of retinoid derivatives as therapeutics in cancer/leukemia. Jack Dixon UCSD SOM Phosphatases in cell division/cancer, axonal pathfinding, and bacterial pathogenesis. Functions of yersinia (Plague) virulence proteins. Daniel Donoghue UCSD Biochem. Receptor tyrosine kinases. FGFR3 signaling in human cancer. FGFR's in developmental syndromes. Cell cycle regulation, cyclin B1 Marilyn Farquhar UCSD SOM Cell signaling and protein trafficking. Cellular and Molecular Mechanisms of Renal Disease Gen-Sheng Feng Burnham Molecular signaling for human and mouse embryonic stem cell self-renewal versus differentiation. Molecular basis of obesity/diabetes Seth Field UCSD SOM Signaling by phosphoinositides in metabolic disease and cancer Hudson Freeze Burnham Glycosylation defects in genetic disease, Muscular dystrophy. Protein glycosylation in Crohn's disease, and colitis. Mark Ginsberg UCSD SOM Integrin signaling in normal and cancer cells Larry Goldstein UCSD SOM Molecular mechanisms of intracellular movement in neurons and the role of transport failure in neurodegenerative diseases Steven Gonias UCSD SOM Regulation of cell physiology by proteases and their cell-surface receptors Roberta Gottlieb Scripps Cardiomyocyte response to hypoxia. Cardiomyocyte apoptosis and protective strategies. Ischemic heart disease Dorit Hanein Burnham Electron cryo-microscopy. Structural characterization of the large macromolecular machines involved in cell motility. Actin cytoskeleton structure and regulation. Ziwei Huang Burnham Receptor-ligand interactions and signal transduction cascades underlying human disease, with a focus on apoptosis Paul Insel UCSD SOM G protein coupled receptors in vascular smooth muscle and cardiac myocytes. G protein regulation. Randall Johnson UCSD Biology Biology of hypoxia, and hypoxic response via the transcription factors HIF-1 alpha and c-jun. Tumor angiogenesis. Michael Karin UCSD SOM Signaling through TNF receptors, MAP kinases, and NF-kB in normal and cancer cells. Host-pathogen signaling mechanisms. Pathogen virulence mechanisms. Robert Liddington Burnham Crystallography of adhesion proteins. Integrin signaling in normal and cancer cells. Virulence factor-host interactions. Thomas Mustelin Burnham Tyrosine phosphatases, cell cycle regulation. T cell activation. T cell receptor signaling. Elena Pasquale Burnham Signaling by Eph receptor tyrosine kinesis. Neuronal development and cancer. Maurizio Pellecchia Burnham Apoptosis and Cell Death, Infectious Diseases John Reed Burnham Apoptosis regulation by Bcl2 family proteins and their regulators. Bing Ren UCSD SOM Genetic targets of oncoproteins and developmental signal pathways. Transcriptional mechanisms. Robert Rickert Burnham B cell signaling during antigen stimulation Ze'ev Ronai Burnham Regulation of the mammalian stress response by ubiquitin and ubiquitin-like proteins David Rose UCSD SOM Signal transduction, nuclear receptors. Coactivator and corepressor exchange mechanisms. Guy Salvesen Burnham Apoptosis pathways. Regulation of the Caspase family of intracellular proteases in cell death. Sanford Shattil UCSD SOM Regulation of integrin signaling by tyrosine kinesis and GTPases in normal and cancer cells. Gernot Walter UCSD SOM Regulation of cell division by Protein Phosphatase 2A (PP2A). PP2A mutations in cancer that cause enzyme deregulation. Ian Wilson Scripps Crystallography of cancer targets, HIV proteins, and immunoreceptors. Tony Yaksh UCSD SOM Mechanisms of pain and pain modulation. Role of mitogen-activated protein (MAP) kinesis in pain signaling. Jing Yang UCSD SOM Tumor Metastasis Mechanisms
©2008 UCSD/Burnham Molecular Pathology Graduate Program