Training for Careers in
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| PhD Program |
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| Burnham Institute |
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| Ludwig Institute, UCSD |
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| Salk Institute |
Stem Cell and Developmental Biology Faculty The Stem Cell and Developmental Biology faculty take a diverse approach to developing technology for regenerative medicine. Among the major emphases are the identification and characterization of stem cell populations in adult tissues and organs, and elucidating the molecular mechanisms that control their self-renewal and differentiation in vivo. The group also conducts research into naturally occurring molecules that promote stem cell renewal, survival and differentiation, and use automated robotics to screen for small molecules, proteins and genes that can be used to modulate stem cell behavior. The range of cells under study include embryonic stem cells (ESCs), including human ESCs, and adult stem cells, as well as tumor stem cells, which are thought to be responsible for the malignant and proliferative potential of numerous cancers. (Research Overview, Additional Activities)
Faculty
Rolf Bodmer Burnham Genetic basis of cardiac development, function and aging. Studying cardiac disease genes in Drosophila as a high-throughput genetic model. Sylvia Evans UCSD SOM Cardiac Lineage Specification, Stem cells, Congenital Heart disease. Gen-Sheng Feng Burnham Molecular signaling for human and mouse embryonic stem cell self-renewal versus differentiation. Molecular basis of obesity/diabetes Xiang-Dong Fu UCSD SOM mRNA splicing regulation in cell type-specificity, general differentiation, and heart development. Fred Gage Salk Neuronal plasticity. Neuronal replacement in Alzheimer's and spinal cord repair Christopher Glass UCSD SOM Transcription regulation by coactivators and corepressors in myeloid differentiation and in leukemia. Monocyte function, atherosclerosis. Mark Kamps UCSD SOM Hemopoietic stem cell differentiation. Biochemical and genetic mechanism of differentiation arrest by human leukemia proteins (E2a-Pbx1, Hoxa9, and Meis1). Fred Levine Burnham Transcriptional regulation in pancreatic beta cells. Pancreatic stem cell differentiation. Stem cell applications in diabetes Stuart Lipton Burnham Neurodegeneration mechanisms in stroke, dementia & AIDS. Stem cell therapies. Mark Mercola Burnham Cardiac stem cells in development and regeneration. Patterning left-right asymmetry during development. TGF-b and Wnt signaling. Robert Oshima Burnham Ets transcription factors, mouse tumor models, placental development Bing Ren UCSD SOM Genetic targets of oncoproteins and developmental signal pathways. Transcriptional mechanisms. Geoff Rosenfeld UCSD SOM Transcription regulation of brain development. Coactivator and Corepressor mechanisms. Neuronal and endocrine disease. Evan Snyder Burnham Stem cells in neural development and regeneration. Neurodegenerative disease. Neuronal gene therapy, transplantation. Oncogenesis and brain tumors. Alexey Terskikh Burnham Genetic mechanisms that maintain hematopoietic, neuronal, and embryonic stem cells Bruce Torbett Scripps Transcription regulation in myeloid differentiation. Myeloid leukemia. HIV protease structure/function and HIV resistance mechanisms.
©2008 UCSD/Burnham Molecular Pathology Graduate Program