Training for Careers in
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Cardiovascular Muscle and Organ Faculty Our goal is to understand genetic and molecular pathways underlying normal development, physiology and pathophysiology of organ systems, including the heart, skeletal muscle, vasculature and immune system, kidney, pancreas, and colon. Many of the faculty are investigating potential stem cell populations which may be of future therapeutic value. (Research Overview, Additional Activities)
Faculty
Roland Blantz UCSD SOM Renal K channels, NMDA receptors. Renal disease in diabetes, inflammation, hypertension Rolf Bodmer Burnham Genetic basis of cardiac development, function and aging. Studying cardiac disease genes in Drosophila as a high-throughput genetic model. Ju Chen UCSD SOM PDZ & LIM proteins in cardiomyocyte function. Cardiac and skeletal muscle disease. David Cheresh UCSD SOM Molecular Basis of Angiogenesis, Vascular-Targeted Gene Delivery, Myocardial Infarction and Stroke Sylvia Evans UCSD SOM Cardiac Lineage Specification, Stem cells, Congenital Heart disease. Hudson Freeze Burnham Glycosylation defects in genetic disease, Muscular dystrophy. Protein glycosylation in Crohn's disease, and colitis. Xiang-Dong Fu UCSD SOM mRNA splicing regulation in cell type-specificity, general differentiation, and heart development. Christopher Glass UCSD SOM Transcription regulation by coactivators and corepressors in myeloid differentiation and in leukemia. Monocyte function, atherosclerosis. Roberta Gottlieb Scripps Cardiomyocyte response to hypoxia. Cardiomyocyte apoptosis and protective strategies. Ischemic heart disease Paul Insel UCSD SOM G protein coupled receptors in vascular smooth muscle and cardiac myocytes. G protein regulation. Martin Kagnoff UCSD SOM Mucosal immunity and inflammation, host mucosal responses to microbial infection, inflammatory bowel disease and celiac disease. Fred Levine Burnham Transcriptional regulation in pancreatic beta cells. Pancreatic stem cell differentiation. Stem cell applications in diabetes Mark Mercola Burnham Cardiac stem cells in development and regeneration. Patterning left-right asymmetry during development. TGF-b and Wnt signaling. Diane Shelton UCSD SOM Cat and dog models of Muscular dystrophy and other neuromuscular diseases Francisco Villarreal UCSD SOM Pathophysiology of cardiac remodeling
©2008 UCSD/Burnham Molecular Pathology Graduate Program