Training for Careers in
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| PhD Program |
| Program Overview |
| All Faculty |
| Faculty Research Groups - Click Banner Insignias |
| Admissions |
| Info for MSTP applicants |
| Info for Current Students |
| Class Offerings |
| Curriculum |
| Financial Support |
| Annual Research Retreat |
| Research Seminars Calendar |
| Med-Into-Grad Program |
| Local Scientific Resources |
| Burnham Institute |
| The UCSD Cancer Center |
| Ludwig Institute, UCSD |
| Scripps Research Institute |
| Salk Institute |
Cancer Biology Faculty The goal of research within the Cancer Biology program is to understand the molecular mechanisms regulating mitogenic signal transduction, the cell cycle, cell differentiation, cell adhesion & migration, and DNA repair. Students are trained to resolve the molecular mechanisms underlying these processes, using cellular, biochemical, molecular, and genetic approaches (Research Overview, Additional Activities)
Faculty
Jack Bui UCSD SOM Immunologic recognition of tumors Dennis Carson UCSD SOM Autoimmune Disease, Cancers of the lymphoid tissues David Cheresh UCSD SOM Molecular Basis of Angiogenesis, Vascular-Targeted Gene Delivery, Myocardial Infarction and Stroke Sara Courtneidge Burnham Src family kinases in normal cell biology and cancer Marcia Dawson Burnham Drug discovery, molecular targets. Synthesis of retinoid derivatives as therapeutics in cancer/leukemia. Daniel Donoghue UCSD Biochem. Receptor tyrosine kinases. FGFR3 signaling in human cancer. FGFR's in developmental syndromes. Cell cycle regulation, cyclin B1 Seth Field UCSD SOM Signaling by phosphoinositides in metabolic disease and cancer Hudson Freeze Burnham Glycosylation defects in genetic disease, Muscular dystrophy. Protein glycosylation in Crohn's disease, and colitis. Minoru Fukuda Burnham Carbohydrate-dependent cell recognition and tumor metastasis. Mark Ginsberg UCSD SOM Integrin signaling in normal and cancer cells Christopher Glass UCSD SOM Transcription regulation by coactivators and corepressors in myeloid differentiation and in leukemia. Monocyte function, atherosclerosis. Steven Gonias UCSD SOM Regulation of cell physiology by proteases and their cell-surface receptors Dorit Hanein Burnham Electron cryo-microscopy. Structural characterization of the large macromolecular machines involved in cell motility. Actin cytoskeleton structure and regulation. Ziwei Huang Burnham Receptor-ligand interactions and signal transduction cascades underlying human disease, with a focus on apoptosis Randall Johnson UCSD Biology Biology of hypoxia, and hypoxic response via the transcription factors HIF-1 alpha and c-jun. Tumor angiogenesis. Mark Kamps UCSD SOM Hemopoietic stem cell differentiation. Biochemical and genetic mechanism of differentiation arrest by human leukemia proteins (E2a-Pbx1, Hoxa9, and Meis1). Michael Karin UCSD SOM Signaling through TNF receptors, MAP kinases, and NF-kB in normal and cancer cells. Host-pathogen signaling mechanisms. Pathogen virulence mechanisms. Thomas Kipps UCSD SOM Immunology, Gene therapy, Lymphoma, Neoplasia, Chronic lymphocytic leukemia, Arthritis Richard Klemke UCSD SOM Molecular Signaling in Metastatic Cancer Cell Invasion Robert Liddington Burnham Crystallography of adhesion proteins. Integrin signaling in normal and cancer cells. Virulence factor-host interactions. Thomas Mustelin Burnham Tyrosine phosphatases, cell cycle regulation. T cell activation. T cell receptor signaling. Robert Oshima Burnham Ets transcription factors, mouse tumor models, placental development Elena Pasquale Burnham Signaling by Eph receptor tyrosine kinesis. Neuronal development and cancer. Maurizio Pellecchia Burnham Apoptosis and Cell Death, Infectious Diseases Manuel Perucho Burnham DNA-repair systems in normal cells and their mutation in cancer cells. James Quigley Scripps Metalloproteinases in tumor metastasis and angiogenesis. Transmembrane proteins in cancer progression. John Reed Burnham Apoptosis regulation by Bcl2 family proteins and their regulators. Bing Ren UCSD SOM Genetic targets of oncoproteins and developmental signal pathways. Transcriptional mechanisms. Ze'ev Ronai Burnham Regulation of the mammalian stress response by ubiquitin and ubiquitin-like proteins Guy Salvesen Burnham Apoptosis pathways. Regulation of the Caspase family of intracellular proteases in cell death. Sanford Shattil UCSD SOM Regulation of integrin signaling by tyrosine kinesis and GTPases in normal and cancer cells. Bruce Torbett Scripps Transcription regulation in myeloid differentiation. Myeloid leukemia. HIV protease structure/function and HIV resistance mechanisms. Ajit Varki UCSD SOM Sialic-acid-binding proteins in innate immunity and tumor metastasis. Sialic acids in host-pathogen interactions. Gernot Walter UCSD SOM Regulation of cell division by Protein Phosphatase 2A (PP2A). PP2A mutations in cancer that cause enzyme deregulation. Ian Wilson Scripps Crystallography of cancer targets, HIV proteins, and immunoreceptors. Jing Yang UCSD SOM Tumor Metastasis Mechanisms
©2008 UCSD/Burnham Molecular Pathology Graduate Program