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All Molecular Pathology Faculty

All faculty participating in the Molecular Pathology program.

Roland Blantz UCSD SOM  Renal K channels, NMDA receptors. Renal disease in diabetes, inflammation, hypertension
Rolf Bodmer Burnham  Genetic basis of cardiac development, function and aging. Studying cardiac disease genes in Drosophila as a high-throughput genetic model.
Jack Bui UCSD SOM  Immunologic recognition of tumors
Nigel Calcutt UCSD SOM  Peripheral nerve disease. Diabetic and Human Immunodeficiency Virus (HIV) neuropathy.
Dennis Carson UCSD SOM  Autoimmune Disease, Cancers of the lymphoid tissues
Ju Chen UCSD SOM  PDZ & LIM proteins in cardiomyocyte function. Cardiac and skeletal muscle disease.
David Cheresh UCSD SOM  Molecular Basis of Angiogenesis, Vascular-Targeted Gene Delivery, Myocardial Infarction and Stroke
Don Cleveland UCSD Ludwig Institute  Molecular genetics of axonal growth and motor neuron disease. Molecular genetics of mammalian chromosome movement and spindle assembly
Sara Courtneidge Burnham  Src family kinases in normal cell biology and cancer
Marcia Dawson Burnham  Drug discovery, molecular targets. Synthesis of retinoid derivatives as therapeutics in cancer/leukemia.
Jack Dixon UCSD SOM  Phosphatases in cell division/cancer, axonal pathfinding, and bacterial pathogenesis. Functions of yersinia (Plague) virulence proteins.
Daniel Donoghue UCSD Biochem.  Receptor tyrosine kinases. FGFR3 signaling in human cancer. FGFR's in developmental syndromes. Cell cycle regulation, cyclin B1
Lars Eckmann UCSD SOM  Cellular and molecular pathogenesis of enteric infections. Mechanisms of intestinal host defense and inflammation.
Sylvia Evans UCSD SOM  Cardiac Lineage Specification, Stem cells, Congenital Heart disease.
Marilyn Farquhar UCSD SOM  Cell signaling and protein trafficking. Cellular and Molecular Mechanisms of Renal Disease
Gen-Sheng Feng Burnham  Molecular signaling for human and mouse embryonic stem cell self-renewal versus differentiation. Molecular basis of obesity/diabetes
Seth Field UCSD SOM  Signaling by phosphoinositides in metabolic disease and cancer
Joshua Fierer UCSD SOM  Polymorphonuclear leukocytes and innate immunity to Salmonella infections in mice. Acquired and natural immunity to Coccidioides immitis.
Hudson Freeze Burnham  Glycosylation defects in genetic disease, Muscular dystrophy. Protein glycosylation in Crohn's disease, and colitis.
Xiang-Dong Fu UCSD SOM  mRNA splicing regulation in cell type-specificity, general differentiation, and heart development.
Minoru Fukuda Burnham  Carbohydrate-dependent cell recognition and tumor metastasis.
Fred Gage Salk  Neuronal plasticity. Neuronal replacement in Alzheimer's and spinal cord repair
Richard Gallo UCSD SOM  Antimicrobial defense mechanisms. Innate immune mechanisms in skin and saliva. Bactericidal peptides.
Frances Gillin UCSD SOM  Molecular biology of the Giardia life cycle. Giardia pathology.
Mark Ginsberg UCSD SOM  Integrin signaling in normal and cancer cells
Christopher Glass UCSD SOM  Transcription regulation by coactivators and corepressors in myeloid differentiation and in leukemia. Monocyte function, atherosclerosis.
Larry Goldstein UCSD SOM  Molecular mechanisms of intracellular movement in neurons and the role of transport failure in neurodegenerative diseases
Steven Gonias UCSD SOM  Regulation of cell physiology by proteases and their cell-surface receptors
John Guatelli UCSD SOM  Nef protein function in human immunodeficiency virus (HIV) infection.
Dorit Hanein Burnham  Electron cryo-microscopy. Structural characterization of the large macromolecular machines involved in cell motility. Actin cytoskeleton structure and regulation.
Paul Insel UCSD SOM  G protein coupled receptors in vascular smooth muscle and cardiac myocytes. G protein regulation.
Martin Kagnoff UCSD SOM  Mucosal immunity and inflammation, host mucosal responses to microbial infection, inflammatory bowel disease and celiac disease.
Mark Kamps UCSD SOM  Hemopoietic stem cell differentiation. Biochemical and genetic mechanism of differentiation arrest by human leukemia proteins (E2a-Pbx1, Hoxa9, and Meis1).
Michael Karin UCSD SOM  Signaling through TNF receptors, MAP kinases, and NF-kB in normal and cancer cells. Host-pathogen signaling mechanisms. Pathogen virulence mechanisms.
Thomas Kipps UCSD SOM  Immunology, Gene therapy, Lymphoma, Neoplasia, Chronic lymphocytic leukemia, Arthritis
Richard Klemke UCSD SOM  Molecular Signaling in Metastatic Cancer Cell Invasion
Edward Koo UCSD SOM  Cellular mechanisms of neurodegenerative diseases, especially Alzheimer's disease
Fred Levine Burnham  Transcriptional regulation in pancreatic beta cells. Pancreatic stem cell differentiation. Stem cell applications in diabetes
Robert Liddington Burnham  Crystallography of adhesion proteins. Integrin signaling in normal and cancer cells. Virulence factor-host interactions.
Jonathan Lin UCSD SOM  Protein Misfolding in Disease and Development
Stuart Lipton Burnham  Neurodegeneration mechanisms in stroke, dementia & AIDS. Stem cell therapies.
Eliezer Masliah UCSD SOM  Mechanisms of synaptic damage. Neurodegeneration mechanisms in Alzheimer’s, Parkinson's, and HIV.
Mark Mercola Burnham  Cardiac stem cells in development and regeneration. Patterning left-right asymmetry during development. TGF-b and Wnt signaling.
Andrew Mizisin UCSD SOM  Peripheral nerve disease, Metabolic & toxic neuropathy. Pathogenesis of diabetic neuropathy.
Victor Nizet UCSD SOM  Streptococcal virulence mechanisms. Invasion. Bacterial infections, meningitis, toxic shock.
Robert Oshima Burnham  Ets transcription factors, mouse tumor models, placental development
Mana Parast UCSD SOM Trophoblast differentiation and placental development: role of PPAR
transcription factors and hypoxia.
Elena Pasquale UCSD SOM   Cell signaling and protein trafficking. Cellular and Molecular Mechanism of Renal Disease.
Maurizio Pellecchia Burnham  Apoptosis and Cell Death, Infectious Diseases
Manuel Perucho Burnham  DNA-repair systems in normal cells and their mutation in cancer cells.
James Quigley Scripps  Metalloproteinases in tumor metastasis and angiogenesis. Transmembrane proteins in cancer progression.
John Reed Burnham  Apoptosis regulation by Bcl2 family proteins and their regulators.
Sharon Reed UCSD SOM  Virulence factors in protozoan parasites, Entamoeba histolytica; Toxoplasma gondii.
Bing Ren UCSD SOM  Genetic targets of oncoproteins and developmental signal pathways. Transcriptional mechanisms.
Douglas Richman UCSD SOM  Human Immunodeficiency Virus (HIV) neutralization, immune evasion.
Robert Rickert Burnham  B cell signaling during antigen stimulation
Ze'ev Ronai Burnham  Regulation of the mammalian stress response by ubiquitin and ubiquitin-like proteins
David Rose UCSD SOM  Signal transduction, nuclear receptors. Coactivator and corepressor exchange mechanisms.
Geoff Rosenfeld UCSD SOM  Transcription regulation of brain development. Coactivator and Corepressor mechanisms. Neuronal and endocrine disease.
Guy Salvesen Burnham  Apoptosis pathways. Regulation of the Caspase family of intracellular proteases in cell death.
Sanford Shattil UCSD SOM  Regulation of integrin signaling by tyrosine kinesis and GTPases in normal and cancer cells.
Diane Shelton UCSD SOM  Cat and dog models of Muscular dystrophy and other neuromuscular diseases
Christina Sigurdson UCSD SOM  The molecular pathogenesis of transmissible spongiform encephalopathies (TSEs),
Evan Snyder Burnham  Stem cells in neural development and regeneration. Neurodegenerative disease. Neuronal gene therapy, transplantation. Oncogenesis and brain tumors.
Deborah Spector UCSD Biology  Molecular biology & pathogenesis of Human Cytomegliovirus (HCMV), birth defects.
Robert Terkeltaub UCSD SOM  Mechanisms of osteoarthritis
Alexey Terskikh Burnham  Genetic mechanisms that maintain hematopoietic, neuronal, and embryonic stem cells
Bruce Torbett Scripps  Transcription regulation in myeloid differentiation. Myeloid leukemia. HIV protease structure/function and HIV resistance mechanisms.
Ajit Varki UCSD SOM  Sialic-acid-binding proteins in innate immunity and tumor metastasis. Sialic acids in host-pathogen interactions.
Francisco Villarreal UCSD SOM  Pathophysiology of cardiac remodeling
Joseph Vinetz UCSD SOM  Malaria and leptospirosis. Strategies of blocking malaria transmission. Mechanisms leptospirosis pathogenesis.
Gernot Walter UCSD SOM  Regulation of cell division by Protein Phosphatase 2A (PP2A). PP2A mutations in cancer that cause enzyme deregulation.
Ian Wilson Scripps  Crystallography of cancer targets, HIV proteins, and immunoreceptors.
Tony Yaksh UCSD SOM  Mechanisms of pain and pain modulation. Role of mitogen-activated protein (MAP) kinesis in pain signaling.
Jing Yang UCSD SOM  Tumor Metastasis Mechanisms
Dong-Er Zhang UCSD Pathology and Molecular Biology   The molecular pathology of cancer development, progression, and treatment.

 

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©2008 UCSD/Burnham Molecular Pathology Graduate Program