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All Molecular Pathology Faculty

All faculty participating in the Molecular Pathology program.

Roland Blantz	UCSD SOM	Renal K channels, NMDA receptors. Renal disease in diabetes, inflammation, hypertension
Rolf Bodmer	Burnham	Genetic basis of cardiac development, function and aging. Studying cardiac disease genes in Drosophila as a high-throughput genetic model.
Jack Bui	UCSD SOM	Immunologic recognition of tumors
Nigel Calcutt	UCSD SOM	Peripheral nerve disease. Diabetic and Human Immunodeficiency Virus (HIV) neuropathy.
Dennis Carson	UCSD SOM	Autoimmune Disease, Cancers of the lymphoid tissues
Ju Chen	UCSD SOM	PDZ & LIM proteins in cardiomyocyte function. Cardiac and skeletal muscle disease.
David Cheresh	UCSD SOM	Molecular Basis of Angiogenesis, Vascular-Targeted Gene Delivery, Myocardial Infarction and Stroke
Don Cleveland	UCSD Ludwig Institute	Molecular genetics of axonal growth and motor neuron disease. Molecular genetics of mammalian chromosome movement and spindle assembly
Sara Courtneidge	Burnham	Src family kinases in normal cell biology and cancer
Marcia Dawson	Burnham	Drug discovery, molecular targets. Synthesis of retinoid derivatives as therapeutics in cancer/leukemia.
Jack Dixon	UCSD SOM	Phosphatases in cell division/cancer, axonal pathfinding, and bacterial pathogenesis. Functions of yersinia (Plague) virulence proteins.
Daniel Donoghue	UCSD Biochem.	Receptor tyrosine kinases. FGFR3 signaling in human cancer. FGFR's in developmental syndromes. Cell cycle regulation, cyclin B1
Lars Eckmann	UCSD SOM	Cellular and molecular pathogenesis of enteric infections. Mechanisms of intestinal host defense and inflammation.
Sylvia Evans	UCSD SOM	Cardiac Lineage Specification, Stem cells, Congenital Heart disease.
Marilyn Farquhar	UCSD SOM	Cell signaling and protein trafficking. Cellular and Molecular Mechanisms of Renal Disease
Gen-Sheng Feng	Burnham	Molecular signaling for human and mouse embryonic stem cell self-renewal versus differentiation. Molecular basis of obesity/diabetes
Seth Field	UCSD SOM	Signaling by phosphoinositides in metabolic disease and cancer
Joshua Fierer	UCSD SOM	Polymorphonuclear leukocytes and innate immunity to Salmonella infections in mice. Acquired and natural immunity to Coccidioides immitis.
Hudson Freeze	Burnham	Glycosylation defects in genetic disease, Muscular dystrophy. Protein glycosylation in Crohn's disease, and colitis.
Xiang-Dong Fu	UCSD SOM	mRNA splicing regulation in cell type-specificity, general differentiation, and heart development.
Minoru Fukuda	Burnham	Carbohydrate-dependent cell recognition and tumor metastasis.
Fred Gage	Salk	Neuronal plasticity. Neuronal replacement in Alzheimer's and spinal cord repair
Richard Gallo	UCSD SOM	Antimicrobial defense mechanisms. Innate immune mechanisms in skin and saliva. Bactericidal peptides.
Frances Gillin	UCSD SOM	Molecular biology of the Giardia life cycle. Giardia pathology.
Mark Ginsberg	UCSD SOM	Integrin signaling in normal and cancer cells
Christopher Glass	UCSD SOM	Transcription regulation by coactivators and corepressors in myeloid differentiation and in leukemia. Monocyte function, atherosclerosis.
Larry Goldstein	UCSD SOM	Molecular mechanisms of intracellular movement in neurons and the role of transport failure in neurodegenerative diseases
Steven Gonias	UCSD SOM	Regulation of cell physiology by proteases and their cell-surface receptors
John Guatelli	UCSD SOM	Nef protein function in human immunodeficiency virus (HIV) infection.
Dorit Hanein	Burnham	Electron cryo-microscopy. Structural characterization of the large macromolecular machines involved in cell motility. Actin cytoskeleton structure and regulation.
Paul Insel	UCSD SOM	G protein coupled receptors in vascular smooth muscle and cardiac myocytes. G protein regulation.
Martin Kagnoff	UCSD SOM	Mucosal immunity and inflammation, host mucosal responses to microbial infection, inflammatory bowel disease and celiac disease.
Mark Kamps	UCSD SOM	Hemopoietic stem cell differentiation. Biochemical and genetic mechanism of differentiation arrest by human leukemia proteins (E2a-Pbx1, Hoxa9, and Meis1).
Michael Karin	UCSD SOM	Signaling through TNF receptors, MAP kinases, and NF-kB in normal and cancer cells. Host-pathogen signaling mechanisms. Pathogen virulence mechanisms.
Thomas Kipps	UCSD SOM	Immunology, Gene therapy, Lymphoma, Neoplasia, Chronic lymphocytic leukemia, Arthritis
Richard Klemke	UCSD SOM	Molecular Signaling in Metastatic Cancer Cell Invasion
Edward Koo	UCSD SOM	Cellular mechanisms of neurodegenerative diseases, especially Alzheimer's disease
Fred Levine	Burnham	Transcriptional regulation in pancreatic beta cells. Pancreatic stem cell differentiation. Stem cell applications in diabetes
Robert Liddington	Burnham	Crystallography of adhesion proteins. Integrin signaling in normal and cancer cells. Virulence factor-host interactions.
Jonathan Lin	UCSD SOM	Protein Misfolding in Disease and Development
Stuart Lipton	Burnham	Neurodegeneration mechanisms in stroke, dementia & AIDS. Stem cell therapies.
Eliezer Masliah	UCSD SOM	Mechanisms of synaptic damage. Neurodegeneration mechanisms in Alzheimer’s, Parkinson's, and HIV.
Mark Mercola	Burnham	Cardiac stem cells in development and regeneration. Patterning left-right asymmetry during development. TGF-b and Wnt signaling.
Andrew Mizisin	UCSD SOM	Peripheral nerve disease, Metabolic & toxic neuropathy. Pathogenesis of diabetic neuropathy.
Victor Nizet	UCSD SOM	Streptococcal virulence mechanisms. Invasion. Bacterial infections, meningitis, toxic shock.
Robert Oshima	Burnham	Ets transcription factors, mouse tumor models, placental development
Mana Parast	UCSD SOM	Trophoblast differentiation and placental development: role of PPAR transcription factors and hypoxia.
Elena Pasquale	UCSD SOM	Cell signaling and protein trafficking. Cellular and Molecular Mechanism of Renal Disease.
Maurizio Pellecchia	Burnham	Apoptosis and Cell Death, Infectious Diseases
Manuel Perucho	Burnham	DNA-repair systems in normal cells and their mutation in cancer cells.
James Quigley	Scripps	Metalloproteinases in tumor metastasis and angiogenesis. Transmembrane proteins in cancer progression.
John Reed	Burnham	Apoptosis regulation by Bcl2 family proteins and their regulators.
Sharon Reed	UCSD SOM	Virulence factors in protozoan parasites, Entamoeba histolytica; Toxoplasma gondii.
Bing Ren	UCSD SOM	Genetic targets of oncoproteins and developmental signal pathways. Transcriptional mechanisms.
Douglas Richman	UCSD SOM	Human Immunodeficiency Virus (HIV) neutralization, immune evasion.
Robert Rickert	Burnham	B cell signaling during antigen stimulation
Ze'ev Ronai	Burnham	Regulation of the mammalian stress response by ubiquitin and ubiquitin-like proteins
David Rose	UCSD SOM	Signal transduction, nuclear receptors. Coactivator and corepressor exchange mechanisms.
Geoff Rosenfeld	UCSD SOM	Transcription regulation of brain development. Coactivator and Corepressor mechanisms. Neuronal and endocrine disease.
Guy Salvesen	Burnham	Apoptosis pathways. Regulation of the Caspase family of intracellular proteases in cell death.
Sanford Shattil	UCSD SOM	Regulation of integrin signaling by tyrosine kinesis and GTPases in normal and cancer cells.
Diane Shelton	UCSD SOM	Cat and dog models of Muscular dystrophy and other neuromuscular diseases
Christina Sigurdson	UCSD SOM	The molecular pathogenesis of transmissible spongiform encephalopathies (TSEs),
Evan Snyder	Burnham	Stem cells in neural development and regeneration. Neurodegenerative disease. Neuronal gene therapy, transplantation. Oncogenesis and brain tumors.
Deborah Spector	UCSD Biology	Molecular biology & pathogenesis of Human Cytomegliovirus (HCMV), birth defects.
Robert Terkeltaub	UCSD SOM	Mechanisms of osteoarthritis
Alexey Terskikh	Burnham	Genetic mechanisms that maintain hematopoietic, neuronal, and embryonic stem cells
Bruce Torbett	Scripps	Transcription regulation in myeloid differentiation. Myeloid leukemia. HIV protease structure/function and HIV resistance mechanisms.
Ajit Varki	UCSD SOM	Sialic-acid-binding proteins in innate immunity and tumor metastasis. Sialic acids in host-pathogen interactions.
Francisco Villarreal	UCSD SOM	Pathophysiology of cardiac remodeling
Joseph Vinetz	UCSD SOM	Malaria and leptospirosis. Strategies of blocking malaria transmission. Mechanisms leptospirosis pathogenesis.
Gernot Walter	UCSD SOM	Regulation of cell division by Protein Phosphatase 2A (PP2A). PP2A mutations in cancer that cause enzyme deregulation.
Ian Wilson	Scripps	Crystallography of cancer targets, HIV proteins, and immunoreceptors.
Tony Yaksh	UCSD SOM	Mechanisms of pain and pain modulation. Role of mitogen-activated protein (MAP) kinesis in pain signaling.
Jing Yang	UCSD SOM	Tumor Metastasis Mechanisms
Dong-Er Zhang	UCSD Pathology and Molecular Biology	The molecular pathology of cancer development, progression, and treatment.

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©2008 UCSD/Burnham Molecular Pathology Graduate Program