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Modern Drug Discovery Technologies
PATH228/BIOM228/PHAR228Units: 2
Quarter: Sp
Location: The Burnham Institute: Building 10, Room 1308 or 1502, and Building 2, Room 2000
Lectures: 10 A.M.-12:00 P.M. Monday or Tuesday
Demos: 1:00P.M. - 2:00 P.M. Monday or TuesdayCourse Director: Maurizio Pellecchia
This class will be taught on Monday or Friday each week by program faculty whose laboratories are actively involved in discovering and developing small organic molecules against therapeutically relevant targets. The course covers the basic principles of Computer-aided drug design, structure-based drug design, fragment-based drug design, Medicinal chemistry, high- throughput screening, cell-based screens, and progression of drug development from lead compound to commercialized drug. Examples recently published from the laboratories of program faculty will be included. The class also includes two practical sessions in HTS and computational docking (Course Coordinator Dr. Maurizio Pellecchia, additional faculty are Dr. Ziwei Huang, Dr. Jeff Price, Dr. Mark Mercola, Dr. John Cashman (HBRI), Dr. Robert Abraham (Wyeth) and Dr. Tomas Mustelin (Amgen)). Students should email Lloyd Slivka at ( lslivka@burnham.org) to sign up for the course.
Date
Time Title Lecturer Location 4/27 11am-12:00 pm Course Introduction: Introduction to modern pharmaceutical chemistry Target identification and validation Maurizio Pellecchia, Ph.d. Bldg 10
Rm 130812-1:00 pm RNA interference for target identificatioin and validation Tomas Mustelin, Ph.D.
Bldg 10
Rm 13084/28 10am -12 pm High-throughput screening: Asay implementation and development Maurizio Pellecchia, Ph.D
E. SergienkoBldg 10
Rm 13085/4 10am -12 pm Cell-based screening: assay implementation and development Mark Mercola, Ph.D. Bldg 10
Rm 13081:00 -2:00 pm Demo of HTS E. Sergienko Bldg 2
Room 20005/18 10am -12 pm Cell-based screening: assay implementation and development (Part 2) Jeff Price Ph.D. Bldg 10
Rm 15021:00 -2:00 pm Demo S. Heynen Bldg 2
Room 20005/19 10am -12 pm Chemical and Computational Methods for Lead Discovery and Optimization Ziwei Huang, Ph.D. Bldg 10
Rm 15025/25 No Class Memorial Day Holiday 5/26 10am -12 pm Structure and Fragment-based drug discovery Maurizio Pellecchia, Ph.d. Bldg 10
Rm 15021:00 -2:00 pm Demo-Virtual docking and NMR-based Screening Ziwei Huang, Ph.D. Bldg 2
Room 20006/1 10am -12 pm I - Developing rationally-based targeted therapies of cancer.
II- The journey from the gene discovery and preclinical validation to clinical efficacyPaul Fisher , Ph.D. Bldg 10
Rm 13086/2 10am -12 pm Drug metabolism: rescuing and repurposing John Cashman, Ph.D. Bldg 10
Rm 13086/8 10am -12 pm PK,PD, and in-vitro ADME-Tox Russell Dahl, Ph.D. Bldg 10
Rm 15026/9 10am -12 pm Final exam and course evaluation Maurizio Pellecchia, Ph.d. Bldg 10
Rm 1308
©2008 UCSD/Burnham Molecular Pathology Graduate Program