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Mouse Models for Human Disease, PATH 223/BIOM227
Spring Quarter 2009 Course Director: Lars Eckmann Units: 2
Quarter: Sp
Location: MTF 275
Time: Tuesdays, 1:00-3:00 PM
2 Credit Course
2-credit course. In vivo studies are becoming increasingly important in the postgenomic era for validating and extending cellular and molecular approaches into complex physiology. This course provides an overview of the use of mouse models in biomedical research. Initial sessions will discuss general mouse biology and genetics, and technologies for generating mutant mice. This will be followed by several sessions on mouse models in specific areas of human disease research, with a focus on model selection, methodological approaches, and data interpretation. The course will culminate with sessions on experimental design and ethics of animal research. Student participation will include opportunities for discussion as well as 10-15 minutes student presentations of original research papers employing murine models. Attendance required. Grading: S/U
The course will meet Tuesdays from 1 – 3 PM in MTF 275. If there are any questions, please contact the course director under leckmann@ucsd.edu.
Section ID# TBA
COURSE OUTLINE
Date
Day
Time
Lecture Topic
Lecturer
3/31 TUE 1:00 - 3:00 Why the Mouse? Introduction to Mice in Biomedical Research and Comparative Genomics of Mice and Man Lars Eckmann 4/7 TUE 1:00 - 3:00 Generation of Transgenic and Gene-targeted Mice Lesley Ellies 4/14 TUE 1:00 - 3:00 Mouse Models of Cardiovascular Disease Francisco Villarea 4/21 TUE 1:00 - 3:00 Mice in Rheumatology Research Maripat Corr 4/28 TUE 1:00 - 3:00 Imaging and Mouse Models in Surgery Michael Bouvet 5/5 TUE 1:00 - 3:00 Inflammation and Infection Models in Mice, Murine Xenotransplantation Models Lars Eckmann 5/12 TUE 1:00 - 3:00 Mouse Models of Cancer Growth and Metastasis Harvey Hershman 5/19 TUE 1:00 - 3:00 Murine Models of Neurological Disorders Eliezer Masliah 5/26 TUE 1:00 - 3:00 Experimental Design and Ethics in Animal Research Mike Kalichman 6/2 TUE 1:00 - 3:00 Regulations and Animal Protocols Debra van Etten Lars Eckmann