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Mouse Models for Human Disease, PATH223/BIOM227
Spring Quarter 2013
Course Directors: Lars Eckmann & Peter ErnstUnits: 2
Quarter: Sp
Location: MET 313
Time: Tuesdays, 1:00-3:00 PM
2-credit course. In vivo studies are becoming increasingly important in the postgenomic era for validating and extending cellular and molecular approaches into complex physiology. This course provides an overview of the use of mouse models in biomedical research. Initial sessions will discuss general mouse biology and genetics, and technologies for generating mutant mice. This will be followed by several sessions on mouse models in specific areas of human disease research, with a focus on model selection, methodological approaches, and data interpretation. The course will culminate with sessions on experimental design and ethics of animal research. Student participation will include opportunities for discussion as well as 10-15 minutes student presentations of original research papers employing murine models. Attendance required. Grading: S/U
If there are any questions, please contact the course director under leckmann@ucsd.edu.
Section Number: Use 769303 for PATH223 and use 778662 for BIOM227
COURSE OUTLINE
Date
Day
Time
Lecture Topic
Lecturer
4/2 TUE 1:00 - 3:00 Why the Mouse? Introduction to Mice in Biomedical Research and Comparative Genomics of Mice and Man Lars Eckmann 4/9 TUE 1:00 - 3:00 Mutant Mouse Technology Lesley Ellies 4/16 TUE 1:00 - 3:00 Experimental Design and Biostatistical Analysis of Animal Studies Peter Ernst 4/23 TUE 1:00 - 3:00 Animal Regulations, Welfare, and Protocols Marilyn Torchia
Lars Eckmann4/30 TUE 1:00 - 3:00 Murine Models for Lung Research Frank Powell 5/7 TUE 1:00 - 3:00 Inflammation and Infection Models in Mice,
Murine Xenotransplantation ModelsLars Eckmann 5/14 TUE 1:00 - 3:00 Mouse Models of Cardiovascular Disease Francisco Villareal 5/21 TUE 1:00 - 3:00 Ethics of Animal Research Mary Devereaux 5/28 TUE 1:00 - 3:00 Behavioral Research in Mice Melanie Gareau 6/4 TUE 1:00 - 3:00 Recognizing and Measuring Disease in Murine Models Peter Ernst