Microbial Pathogenesis

Units: 4
Quarter: Spring
Location: MTF 275
Time: Tuesdays, 8:30 to 11:30 AM

Topics to be covered include molecular and cellular mechanisms of viral, bacterial, and protozoan pathogenesis. Immune defenses of the host will also be addressed. Weekly meetings will consist of faculty overview of principles and student led discussion of key papers. Course Director – Lynette B Corbeil, DVM, PhD, Professor of Pathology.

COURSE OUTLINE

I. Introduction
	A. Course Outline and Expectations
	B. Overview
		1. Virulence Mechanisms 2. Host Defenses 3. Parasite evasion of host defense 4. Enhancing defense with vaccines
II. Bacteria (Lynette Corbeil)
	A. Bordetella spp (L Corbeil)
	B. Streptococcus spp (Victor Nizet)
III. Parasites (Frances Gillian)
	A. Brief introduction to parasites (Gillin)
	B. Giardia (Gillin)
	C. Extracellular Trypanosomes (T. brucei): Africa (Gillin)
	D. Toxoplasma gondii (Sharon Reed)
IV. Viruses (John Guatelli)
	A. Influenza: acute cytopathic infection (Guatelli)
	B. HIV: chronic persistent infection (Guatelli)
	C. HSV: chronic latent infection with episodic reactivation (Guatelli)

STUDENT RESPONSIBILITIES

Attendance required.
Papers will be assigned each week. Students to present the papers will be identified, but all students are responsible for reading all the papers and participating in the discussion.
Students will be evaluated on the basis of presentations, participating in discussion, take home exam/paper results.

Training for Careers in Biomedical Research

Microbial Pathogenesis

Training for Careers in
Biomedical Research