Training for Careers in
|
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PhD Program |
| Program Overview |
| All Faculty |
| Faculty Research Groups - Click Banner Insignias |
| Admissions |
| Info for MSTP applicants |
| Info for Current Students |
| Class Offerings |
| Curriculum |
| Financial Support |
| Annual Research Retreat |
| Research Seminars Calendar |
| Med-Into-Grad Program |
| Local Scientific Resources |
| Burnham Institute |
| The UCSD Cancer Center |
| Ludwig Institute, UCSD |
| Scripps Research Institute |
| Salk Institute |
Units: 4. Course is for letter grade PATH 221: Molecular Pathology of Cancer
Quarter: WI
Location: Leichtag 2a05
Time: Monday/Wednesday 10AM to Noon
This class is taught by program faculty from UCSD and the Burnham Institute whose laboratories are actively engaged in cancer research. It covers a wide range of cancer-related topics at the molecular level and provides a solid basis of knowledge for students interested in the cancer problem. The syllabus below is the NEW line-up for 2010.
Sign up under Pathology Department Offerings
DATE TOPIC LECTURER 1/4 The stem cell theory of cancer. Stem cell properties of teratocarcinoma, breast & colon cancer Robert Oshima 1/6 Stem cell properties of brain cancers and leukemias Alexey Terskikh 1/11 The histopathology of cancer Steve Baird 1/13 P13 kinase signaling in normal and cancer cells Seth Field 1/18 Martin Luther King Junior Holiday No Class 1/20 The HIPPO/YAP pathway in cancer Kun-Liang Guan 1/25 Mechanisms and fish models of cancer cell migration and metastasis Richard Klemke 1/27 Integrins in tumor vascular biology David Cheresh 2/1 Endoplasmic reticulum stress and unfolded protein response signaling pathways in cancer Jonathan Lin 2/3 Hedgehog and RAS signaling in stem cells and cancer cells Ben Yu 2/8 Transcription factor oncoproteins that arrest stem cell differentiation in leukemia Mark Kamps 2/10 The role of extracellular proteases in tissue remodeling and invasive processes Jim Quigley 2/15 Presidents Day Holiday No Class 2/17 Hypoxia, angiogenesis, and cancer Randy Johnson 2/22 Inflammation and cancer Michael Karin 2/24 AML1-Eto mechanisms ofleukemogenesis. Ubiquitin-like modifications in cancer Dong-Er Zhang 3/1 Eph receptors and ephrins in cancer Elena Pasquale 3/3 The multi-step tumor metastasis program Jing Yang 3/8 Tumor Immunology Jack Bui 3/10 Translocation oncogenes in solid tumors Karen Arden 3/15 Cancer drugs and the biological roles of their targets Sara Courtneidge 3/17 Student Proposals in small groups, student feed-back and questions. Enjoyable! One faculty
4 students
HOMEWORK: Each lecturer will provide an original research manuscript
related to their lecture. Students select one of the two manuscripts
corresponding to the two weekly lectures, for their homework assignment,
which is due on Monday of the following week. In the 2 weeks that have only
one lecture, then that single paper is the basis for that weeks homework.
After reading the paper, students answer the following questions:1. What is the major open research question addressed by the authors?
2. What is the author's hypothesis?
3. What do you think is the most important figure, and why?
4. Having read the paper, what is a new important open research question?
5. How would you pursue answering that question experimentally?Your answers may not be longer than one page of single spaced type.
GRADES. The answers will be assigned letter grades and the students will be informed shortly about the grades. An average of B is required in order to pass. The answers should be precise and to the point. Answers should not be longer than 1/2 page.
FINALS. In the "Final", each student will present a short research proposal (10-15 min with 5 minutes for questions) on a topic related to cancer. The proposal should define an open question in cancer research, state a hypothesis for a proposed mechanism, and delineate a number of specific aims, or approaches, that will be used to investigate the question. This is the same thought process you will use for your research proposals that you will need to do by Autumn quarter of your second year. A one page Abstract of the proposal is required on the lecture session prior to the Final proposal date, and student will not have homework questions accompanying either of the last 2 lectures. Your proposal will count as 3 homework grades. The grades of all lectures together with the grade for the Final will be averaged for your final grade.
All lectures need to be attended. Failure to attend a class will result in a D for that session, unless the absence has been pre-arranged (e.g. to attend a meeting).
FACULTY EVALUATIONS: You will be required to do facutly evaluations at the end of the quarter for each faculty member who presents.
©2008 UCSD/Burnham Molecular Pathology Graduate Program