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PATH 221: Molecular Pathology of Cancer
Units: 4. Course is for letter grade
Quarter: Wi
Location: Leichtag 2a05
Time: Monday/Wednesday 10AM to Noon

This class is taught by program faculty from UCSD and the Burnham Institute whose laboratories are actively engaged in cancer research. It covers a wide range of cancer-related topics at the molecular level and provides a solid basis of knowledge for students interested in the cancer problem. The syllabus below is the NEW line-up for 2008.

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DATE TOPIC LECTURER
1/7 The stem cell theory of cancer 2008 Slides Robert Oshima
1/9

The histology of normal and cancer tissues.

2008 Slides Steve Baird
1/14 Ubiquitin ligases and cell cycle control 2008 Slides Ze'ev Ronai
1/16 Receptor tyrosine kinases in cancer 2008 Slides Elena Pasquale
1/21 Martin Luther King Junior Holiday
1/23 PI3 kinase signaling in normal and cancer cells (PDF/Hoa) (PDF/Samuels) 2008 Slides Seth Field
1/28 Tumor Immunology 2008 Slides Jack Bui
1/30 The role of stromal cells in tumor cell viability: The tumor vs stem cell microenvironment
Normal Stem Cell PDF Friends or Foes PDF
2008 Slides Bruce Torbett
2/4 Hedgehog and RAS signaling in stem cells and cancer cells 2008 Slides Ben Yu
2/6 FOXO transcription factors in normal and tumor cells 2008 Slides Karen Arden
2/11 Transcription factor oncoproteins that arrest stem cell differentiation in leukemia 2008 Slides Mark Kamps
2/13 AML1-Eto mechanisms ofleukemogenesis. Ubiquitin-like modifications in cancer. 2008 Slides

Dong-Er Zhang

2/18 Presidents Day Holiday
2/20 Colon and Pancreatic cancers, disruption of Wnt, TGFbeta, and DNA repair pathways2008 Slides John Carethers
2/25 Deregulation of intrinsic apoptotic pathways in cancer 2008 Slides John Reed
2/27 Integrins in tumor vascular biology 2008 Slides David Cheresh
3/3 Hypoxia, angiogenesis, and cancer 2008 Slides Randy Johnson
3/5 Inflammation and cancer 2008 Slides

Michael Karin

3/10 The role of extracellular proteases in tissue remodeling and invasive processes 2008 Slides Jim Quigley
3/12 The multi-step tumor metastasis program 2008 Slides Jing Yang
3/17 Cancer drugs and the biological roles of their targets 2008 Slides

Sara Courtneidge

3/19 Student Proposals in small groups, student feed-back and questions. Enjoyable!

One faculty/4 stud

HOMEWORK. In order to evaluate student performance, students are required to read one paper related to the topic of each lecture and to answer questions about the paper.

QUESTIONS. The paper and questions will be handed out to students after each lecture. Written answers need to be returned at the beginning of the subsequent lecture.

GRADES. The answers will be assigned letter grades and the students will be informed shortly about the grades. An average of B is required in order to pass. The answers should be precise and to the point. Answers should not be longer than 1/2 page.

FINALS. In the "Final", each student will present a short research proposal (10-15 min with 5 minutes for questions) on a topic related to cancer. The proposal should define an open question in cancer research, state a hypothesis for a proposed mechanism, and delineate a number of specific aims, or approaches, that will be used to investigate the question. This is the same thought process you will use for your research proposals that you will need to do by Autumn quarter of your second year. A one page Abstract of the proposal is required on the lecture session prior to the Final proposal date, and student will not have homework questions accompanying either of the last 2 lectures. Your proposal will count as 3 homework grades. The grades of all lectures together with the grade for the Final will be averaged for your final grade.

All lectures need to be attended. Failure to attend a class will result in a D for that session, unless the absence has been pre-arranged (e.g. to attend a meeting).

 

Questions or comments about the program?
©2008 UCSD/Burnham Molecular Pathology Graduate Program

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