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Units: 4 Drugs and Disease: Nervous System Disease and Therapy
PATH220/PHAR255/BIOM255
Quarter: Spring
Location: CMME 2047
Time: 8:30 - 10:00 A.M.This course covers a variety of diseases of the nervous system and illustrates how appreciating mechanisms of disease can lead to new approaches to treatment of the disease. The goal of this class is to develop the ability of students to understand how specific, well- designed experiments lead to the clear understanding of important research questions. Content is divided into five themes, structure and function, muscle and nerve, Spinal cord, CNS pharmacology and CNS neurodegenerative diseases. Each theme will consist of three lectures followed by a group discussion session where research papers pertinent to the theme will be presented and critiqued by students.
COURSE DIRECTORS: Joan Heller Brown and Nigel Calcutt
CONTACT: Joan Heller Brown at jhbrown@ucsd.edu or 858-534-2595
CONTACT: Nigel Calcutt at ncalcutt@ucsd.edu or 858-534-5331
Block Month Date Faculty Subject Structure and Function
1. March 31 Andrew Mizisin (Block Leader) Neuroanatomy/Histology 2. April 2 Joan Heller Brown CNS transmitters 3. 7 Charles Stevens Synaptic Physiology 4. 9 Mizisin/Brown DISCUSSION I Muscle and Nerve 5. April 14 Nigel Calcutt (Block Leader) Peripheral Neuropathy 6. 16 Palmer Taylor Drug Action at the Neuromuscular Junction 7. 21 Diane Shelton Muscular Dystrophies & Myasthenia Gravis 8. 23 Calcutt/Shelton DISCUSSION II CNS Pharmacology 9. April 28 Joan Heller Brown (Block Leader) Therapy of Psychiatric Diseases 10. 30 Ron Kuczenski Methamphetamine 11. May 5 Stuart Lipton Excitotoxicity and Neuroprotective Drug Design 12 7 Brown/Calcutt DISCUSSION III CNS Processing 13. 10:30-12:30 May 11 Tony Yaksh (Block Leader) Neuropathic Pain 14. 9-10 12 Tony Yaksh Treating Neuropathic Pain 14 No Class - BMS Retreat Make up class is Monday, 5/11/08) 15. 19 Christina Sigurdson Prion Disease 16. 21 Yaksh/Calcutt DISCUSSION IV CNS Neurodegeneration 17. May 26 Katerina Akassoglou Multiple Sclerosis 18. 28 Vivian Hook (Block Leader) Alzheimers Disease 19. June 2 Eliezer Masliah Parkinsons 20. 4 Hook/Brown DISCUSSION V 21. 9 TBD EXAM 22. 11 TBD EXAM Notes:
Class mechanics and evaluation methods will be announced shortly before the course begins.
©2008 UCSD/Burnham Molecular Pathology Graduate Program