Molecular Biology of the Cell

Units: 6
Quarter: Au
Location:
Time:

This class highlights the latest understanding of important topics in cell biology and focuses on those pathways that are relate to human disease. Faculty lecture in their areas of expertise, and concentrate on one aspect of their topic they find particularly important. This may be classic experiments that led to a current perspective, a comprehensive current perspective of the field, or a focus on a single emerging area within the field. Generally, the relationship of the topic to human disease is stressed. The class is diverse, as are the speakers' styles. Each lecturer selects a research paper from within their field and uses it to illustrate the mechanics of research investigation--identifying the important question, designing a valid approach to answering the question, and interpreting your data. These manuscripts are hyperlinked to their lecture titles. "Molecular Biology of the Cell" by Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James Watson (4th Edition) is used as a general text for supplemental information, although the program assumes students already know this basic content from undergraduate studies. Chapters related to the lecture topics are indicated to the right of each lecture, and should be reviewed prior to the session.

Homework: For each manuscript accessed through the lecture topic hyperlinks below, students should answer the following homework questions, using one page or less of written text. Please adhere to the homework policy.

Day
Date

Lecture Topic

Faculty/Lecture PDF

Alberts

Mon 9/18 No Class

Tues 9/19 Cell Signaling: Tyrosine Protein Phosphatases/Downstream Pathways Tomas Mustelin
Rev, 15

Mon 9/25 PI3-kinase signaling in health and disease, Paper Seth Field
6

Tues 9/26 Cellular Responses to Tissue Injury/hemorrhage, Molecular Biology of Hemostasis Steve Gonias

Mon 10/2 Intracellular Compartments and Protein Sorting Marilyn Farquhar
12

Tues 10/3 Intracellular Vesicular Traffic Marilyn Farquhar
13

Mon 10/9 Regulation of mRNA Splicing in Cell Biology, Development, and Disease Xiang-Dong Fu
6

Tues 10/10 Cell Cycle Regulation and the DNA-Damage Response Ze'ev Ronai
17

Mon 10/16 Glycosylation Analysis and Congenital Disorders of Glycosylation, Paper 1, Paper 2 Hudson Freeze
13

Tues 10/17 DNA and Chromosomes. The histone code. Robert Oshima
4

Mon 10/23 How Cells Read the Genome: Focus on Transcription Geoff Rosenfeld
6, 7

Tues 10/24 The Cytoskeleton Dorit Hanein
16

Mon 10/30 Membrane Transport and the Electrical Properties of Membranes Dongxian Zhang
11

Tues 10/31 Cell Signaling: Tyrosine Protein Kinases, Adaptors, and Map Kinases Elena Pasquale
15

Mon 11/6 The Proteasome: Basal & Inducible Targeting Mechanisms for Protein Turnover Roberta Gottlieb
7, 21

Tues 11/7 Combinatorial Transcriptional Pathways in Development and Disease Rolf Bodmer
6

Mon 11/13 SMADs and STATs in Signal Transduction, Cell Biology & Disease David Rose
15, 7

Tues 11/14 Integrin Signaling in Health and Disease *Meets 1pm-3pm at Moores Cancer Center in Rm 2242. Meet at shuttle bus loop outside bookstore at 12:30 David Cheresh
19

Mon 11/20 The Adaptive Immune System Robert Rickert
24

Tues 11/21 The Innate Immune System Sharon Reed
25

Mon 11/27 Molecular Pathology of Rheumatic, Allergic, and Autoimmune Disease David Rose
24, 25

Mon 11/27 SECOND LECTURE! Cartilage, Degenerative Arthritis, and Mechanisms of Calcification *Meets from 1pm-3pm in Leichtage 2a05 Robert Terkeltaub
24, 25

Tues 11/28 Structural Approaches to Understanding Pathogenesis Ian Wilson
24, 25

Mon 12/4 No Lecture .

Tues 12/5 HIV Pathogenesis Douglas Richman
Rev, 24

Mon 12/11 The Molecular Pathology of Atherosclerosis, Turn in homework from 12/5. No new homework from this lecture Chris Glass
25

12/12 TUE REMEMBER YOUR REVIEW SESSION FOR HISTOLOGY!

12/14 THU REMEMBER YOUR HISTOLOGY EXAM!

Training for Careers in Biomedical Research

Molecular Biology of the Cell

Date

Lecture Topic

Faculty/Lecture PDF

Alberts

Training for Careers in
Biomedical Research